Current research

Current research and future questions

Main aim:
What is the impact of ‘time to minimal disease activity’ on quality of life, work participation and radiographic joint damage at 2 year follow up in patients newly diagnosed with psoriatic arthritis (PsA)?

Regarding recommendation for the ISPOR group on comparative effectiveness research, we specified our main aim in the expected direction of the effect. Our hypothesis is that patients who achieve MDA very early in their disease course are more likely to have QoL score that come close to the Dutch general population, have absenteeism rates that are comparable to the Dutch general population and do not show radiological progression. We assume that treatment strategies will differ between rheumatologists that may impact the time to achieve MDA. We also assume that reaching MDA is not only dependent on treatment, but likely also be influence by other factors such disease severity at baseline and symptom duration before diagnosis. Furthermore, we assume that QoL and absenteeism could be modified by other factors such as comorbidity.

Secondary aims:
What is the impact of ‘time to minimal disease activity’ on quality of life, work participation and radiographic joint damage at two year follow up in patients newly diagnosed with PsA?
In addition we will gather data among patients with PsA on:

  • What is the frequency of MDA in the first year after diagnosis?
  • Which medication is used in the first year after diagnosis?
  • Which type of medication results in early MDA?
  • Which subtypes of PsA are associated with poor longterm outcome?
  • What is the impact of ‘time to minimal disease activity’ on quality of life, work participation and radiographic joint damage at one and three year follow-up in patients newly diagnosed with PsA?